Rofecoxib is a potent, specific and orally active COX-2 inhibitor, with IC50s of 26 and 18 nM for human COX-2 in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity for COX-2 over human COX-1 (IC50 > 50 µM in U937 cells and > 15 µM in Chinese hamster ovary cells).
Molecular Weight:
314.36
Purity:
99.89
CAS Number:
[162011-90-7]
Formula:
C17H14O4S
Target:
COX
Application Notes:
MCE Product type: Reference compound
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