Rosiglitazone-d3 is the deuterium labeled Rosiglitazone. Rosiglitazone (BRL 49653) is a selective, orally active PPARgamma agonist with EC50s of 30 nM, 100 nM and 60 nM for PPARgamma1, PPARgamma2, and PPARgamma, respectively. Rosiglitazone binds to PPARgamma with a Kd of approximately 40 nM. Rosiglitazone is also an activator of TRPC5 (EC50=~30 µM) and an inhibitor of TRPM3[1][2][3][4].
