Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-kappaB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection[1][2][3][4][5][6].
Molecular Weight:
683.62
Purity:
99.84
CAS Number:
[89226-75-5]
Formula:
C35H40Cl2N4O6
Target:
Calcium Channel,NF-kappaB
Application Notes:
MCE Product type: Reference compound
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