Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits alpha-syn and Abeta42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma[1][2][3][4].
Molecular Weight:
273.24
Purity:
99.91
CAS Number:
[134308-13-7]
Formula:
C14H11NO5
Target:
Amyloid-beta,Apoptosis,COMT,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound1
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