PROTAC GPX4 degrader-4, CAS [[3071165-43-7]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-174086
Supplier Catalog Number:
HY-174086
Alternative Catalog Number:
MCE-HY-174086-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PROTAC GPX4 degrader-4 is a GPX4 PROTAC degrader (DC50: 5.32 nM). PROTAC GPX4 degrader-4 inhibits the activity of RT4, T24, and J82 cancer cells (IC50 values are 0.09, 2.97, and 7.58 µM, respectively). PROTAC GPX4 degrader-4 increases lipid ROS levels and induces ferroptosis in T24 and RT4 cells. PROTAC GPX4 degrader-4 has antitumor activity in T24 tumor-bearing BALB/c nude mouse model. PROTAC GPX4 degrader-4 can be used for bladder cancer research. (Pink: target protein ligand (HY-N0193), blue: E3 ligase ligand (HY-1035960), black: linker (HY-W013907), E3 ligase ligand + linker (HY-174087))[1].
