P2Y1 antagonist 3 (compound 36b) is a blood-brain barrier (BBB)-penetrant P2Y1 antagonist with an IC50 of 0.50 µM. P2Y1 antagonist 3 exhibits protective effects in a rat middle cerebral artery occlusion (MCAO) model and demonstrates neuroprotective activity against oxidative stress by upregulating nuclear Nrf2 protein levels[1].
Molecular Weight:
342.31
Formula:
C19H10N4O3
Target:
P2Y Receptor
Application Notes:
MCE Product type: Reference compound
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