TM471-1 is an orally active and covalent Brutons tyrosine kinase (BTK) inhibitor with IC50 values of 1.3 nM (BTKWT), >40,000 nM (BTKC481S), 7.9 nM (TEC) and 12.4 nM (TXK). TM471-1 inhibits cell growth in vivo and in vitro, arrests cell cycle at G0/G1 phase and induces cell apoptosis[1].
Molecular Weight:
471.55
CAS Number:
[2649008-95-5]
Formula:
C27H29N5O3
Target:
Apoptosis,Btk
Application Notes:
MCE Product type: Reference compound1
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