CW8001 is a covalent XPO1 (Exportin-1) inhibitor with an EC50 value of 1 nM for inhibiting T cell activation. CW8001 prevents nuclear localization of NFAT transcription factors, suppressing expression of inflammatory cytokines like IL-2. CW8001 is promising for research of T cell-driven immune diseases such as graft-versus-host disease (GVHD)[1].
Molecular Weight:
311.22
Formula:
C12H8F3N5O2
Target:
CRM1
Application Notes:
MCE Product type: Reference compound
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