STING Degrader-2 (Compound SI-43) is a STING inhibitor and mutant-specific degrader. STING Degrader-2 can effectively inhibit cGAMP-induced STING activation and significantly reduce the release of IFN-beta and CXCL-10. It inhibits the activity of STING by binding to two pockets of the STING dimer and induces proteasome-independent degradation of mutants STING S154 and STING M155 (DC50 values are 0.31 and 0.76 µM, respectively). STING Degrader-2 can be used to study STING-related autoimmune diseases[1].
Molecular Weight:
790.86
Formula:
C43H39FN4O8S
Target:
STING
Application Notes:
MCE Product type: Reference compound
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