MerTK-IN-2 (compound 15f) is an orally active MerTK inhibitor with an IC50 of 37.5 nM. MerTK-IN-2 can induce apoptosis. MerTK-IN-2 has antitumor activity with IC50 values of 1.79, 18.32, and 2.18 µM for human ovarian cancer cells A2780, breast cancer cells MDA-MB-231, and colon cancer cells HCT116, respectively[1].
Molecular Weight:
404.44
Formula:
C22H21FN6O
Target:
Apoptosis,TAM Receptor
Application Notes:
MCE Product type: Reference compound
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