MXC-017 is a blood-brain barrier (BBB)-penetrant apoptosis inducer that directly targets Vimentin (VIM). MXC-017 prevents radiation-induced glioma stem cell (GSC) formation, while promoting G0/G1 cell cycle arrest and apoptosis. MXC-017 exhibits minimal off-target effects and shows no significant cytotoxicity. MXC-017 significantly prolongs median survival when used in combination with radiation therapy in glioblastoma (GBM) mouse models.
Molecular Weight:
397.49
CAS Number:
[3037024-97-5]
Formula:
C21H23N3O3S
Target:
Apoptosis
Application Notes:
MCE Product type: Reference compound
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