WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with pIC50 (0 h/4 h) = 5.4/7.5 in the DNA-unwinding 5 endpoint assays. WRN-IN-19 shows synthetic lethality in MSI-H (high microsatellite instability) cancer cells[1].
Molecular Weight:
449.47
CAS Number:
[3058652-58-4]
Formula:
C23H26F3N3O3
Target:
DNA/RNA Synthesis
Application Notes:
MCE Product type: Reference compound
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