I3IN-002 is a small-molecule RNA-binding protein IGF2BP3 inhibitor with an IC50 value of approximately 2 µM in SEM cells. I3IN-002 interferes with interaction with m6 A-modified mRNAs, disrupting the stabilization of target genes (such as CDK6, MYC, and BCL2) to inhibit leukemic cell growth, induce cell cycle arrest, and promote apoptosis. I3IN-002 is promising for research of B-cell acute lymphoblastic leukemia[1][2].
Molecular Weight:
431.43
Purity:
99.35
CAS Number:
[552829-57-9]
Formula:
C20H16F3N5OS
Target:
Apoptosis,Insulin Receptor
Application Notes:
MCE Product type: Reference compound
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