SM311 (Compound 10), a chemical probe, is a potent selective irreversible LIMK1 inhibitor (EC50=0.045 µM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimers disease, as well as tumor invasion[1].
Molecular Weight:
431.46
Formula:
C20H19F2N5O2S
Target:
LIM Kinase (LIMK)
Application Notes:
MCE Product type: Reference compound
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