AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822). AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 µM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells[1].
Molecular Weight:
573.57
Formula:
C32H28FNO8
Target:
Akt,Apoptosis,Caspase,PARP,beta-catenin
Application Notes:
MCE Product type: Reference compound
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