WB156 is a dual MDM2 and GSPT1 degrader. WB156 can recruit CRBN (Cereblon, a substrate receptor of the E3 ubiquitin-ligase complex) to induce the ubiquitination-proteasome pathway-mediated degradation of MDM2 and GSPT1. WB156 is promising for research of cancers, such as leukemia[1].
Molecular Weight:
859.84
CAS Number:
[2368944-44-7]
Formula:
C48H48Cl2N6O5
Target:
MDM-2/p53
Application Notes:
MCE Product type: Reference compound
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