NLRP3-IN-79 is an orally active NLRP3 inhibitor. NLRP3-IN-79 inhibits NLRP3 inflammasome with an IC50 of 10.69 nM. NLRP3-IN-79 blocks NLRP3 inflammasome assembly by directly binding to NLRP3 and disrupting the NEK7-NLRP3 interaction. NLRP3-IN-79 can be used for the study of NLRP3-driven diseases model, including systemic inflammation, peritonitis, and colitis[1].
Molecular Weight:
392.49
Purity:
99.1000
CAS Number:
[3088796-72-6]
Formula:
C23H28N4O2
Target:
Interleukin Related,NEKs,NOD-like Receptor (NLR)
Application Notes:
MCE Product type: Reference compound
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