Modzatinib (ITK kinase-IN-1) (compound I) is an inhibitor targeting ITK kinase (IC50=8 nM, Jurkat cells) and can be used to study inflammatory diseases. Modzatinib has an IC50 of 23 nM for JAK3 in hPBMC cells (based on IL-2/pSTAT5 levels), wihout inhibitory effect against JAK2[1].
Molecular Weight:
361.39
Purity:
98.54
CAS Number:
[2411407-25-3]
Formula:
C18H21F2N5O
Target:
Itk,JAK
Application Notes:
MCE Product type: Reference compound
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