ZSA-215 is a potent and orally active STING agonist with an EC50 of 3.3 µM. ZSA-215 enhances STING signaling through promoting the phosphorylation of STING and interferon regulatory factor 3 (IRF3) and secretion of IFN-beta. ZSA-215 inhibits tumor regression and long-term survival of mice in MC38 colon cancer model. ZSA-215 can be used to the study of colon cancerr[1].
Molecular Weight:
402.28
Formula:
C16H18FNO5Se
Target:
STING
Application Notes:
MCE Product type: Reference compound
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