NLRP3-IN-81, CAS [[2922814-85-3]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-174312
Supplier Catalog Number:
HY-174312
Alternative Catalog Number:
MCE-HY-174312-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
NLRP3-IN-81 (N102) is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 µM against cell pyroptosis induced by Nigericin (HY-127019). NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1beta. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes[1].
