Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 µM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-kappaB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires disease research[1].
Molecular Weight:
439.27
Formula:
C17H25Cl2N2O5P
Target:
Bacterial,Collagen,Toll-like Receptor (TLR)
Application Notes:
MCE Product type: Reference compound1
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