A2073 is a flavagline derivative that potently inhibits the proliferation of erythroleukemia cells by causing cell cycle arrest and suppressing the MAPK, NF-kappaB, and PI3K signaling pathways. A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1). A2073 exhibits significant anti-proliferative activity against tumor cells while maintaining a favorable toxicity profile in a zebrafish xenograft tumor model. A2073 can be used for the study of acute erythroleukemia[1].
Molecular Weight:
559.65
CAS Number:
[2834742-70-8]
Formula:
C33H37NO7
Target:
Akt,NF-kappaB,p38 MAPK,PI3K
Application Notes:
MCE Product type: Reference compound1
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