Skp2-IN-4 is an Skp2 inhibitor with a IC50 of 0.38 µM for Skp2-Cks1 binding. Skp2-IN-4 improves anti-tumor activity, inhibits the proliferation and induces S phase arrest by targeting Skp2. Skp2-IN-4 significantly enhances Cisplatin (HY-17394) chemosensitivity by suppressing the tumor cell stemness in NCl-H1299 xenograft mice model, promising for lung cancer and esophageal cancer research[1].
Molecular Weight:
377.44
Purity:
98.02
Formula:
C24H19N5
Target:
Apoptosis,DNA/RNA Synthesis,E1/E2/E3 Enzyme
Application Notes:
MCE Product type: Reference compound
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