ROR1-IN-3 (Compound 24d) is a potent and highly selective ROR1 kinase inhibitor (IC50 = 17.6 nM). ROR1-IN-3 demonstrates robust antitumor activity and inhibitory effect against ROR1 both in vitro and in vivo. ROR1-IN-3 has robust antiproliferative efficacy in vitro and in vivo. ROR1-IN-3 induces apoptosis in cancer cell lines. ROR1-IN-3 inhibits ROR1 downstream AKT/mTOR and NF-kappaB signaling pathway. ROR1-IN-3 can be studied in antitumor research[1].
Molecular Weight:
596.68
Formula:
C36H32N6O3
Target:
Akt,Apoptosis,mTOR,NF-kappaB,ROR
Application Notes:
MCE Product type: Reference compound1
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