AChE/BChE-IN-27 is a blood-brain barrier-permeable mixed inhibitor (Pe = 4.12) of AChE and BChE, with IC50 values of 3.72 µM and 9.65 µM, respectively. AChE/BChE-IN-27 has potent antioxidant activity with an IC50 value of 6.32 µM in the DPPH (HY-112053) assay and also exhibits potent in vitro antioxidant activity. AChE/BChE-IN-27 exhibits metal chelating properties. AChE/BChE-IN-27 has neuroprotective potential against oxidative stress. AChE/BChE-IN-27 significantly reduces intracellular reactive oxygen species (ROS). In in vivo experiments, AChE/BChE-IN-27 effectively restored AChE and BChE levels, improved cognition, and can be used for Alzheimers disease (AD)[1].
Molecular Weight:
379.41
Formula:
C21H21N3O4
Target:
Cholinesterase (ChE),Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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