ZSH-2117 is a covalent and selective EGFR PROTAC degrader with a DC50 of 45 nM in Ba/F3-EGFRL858R/T790M/C797S cells. ZSH-2117 significantly inhibits cell proliferation and reduces the downstream EGFR signaling proteins level of AKT and ERK. ZSH-2117 effectively inhibits tumor growth in Ba/F3-EGFRL858R/T790M/C797S xenograft mice model[1]. Pink: EGFR ligand (HY-175162), Blue: NEDD4 ligase ligand (HY-175159), Black: linker
Molecular Weight:
762.08
Formula:
C36H39BrClN8O2P
Target:
Akt,EGFR,ERK,PROTACs
Application Notes:
MCE Product type: Reference compound
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