PROTAC JAK2 degrader-1 (Compound 10i) is a JAK2 PROTAC degrader with a DC50 of 27.35 nM for JAK2 V617F. PROTAC JAK2 degrader-1 promotes the ubiquitination and degradation of JAK2. PROTAC JAK2 degrader-1 inhibits the phosphorylation of JAK2, STAT3 and STAT5. PROTAC JAK2 degrader-1 can be used in the research of myeloproliferative neoplasms (Pink: JAK2 ligand (HY-174430), Blue: E3 ligase ligand (HY-W087383), Black: E3 ligase ligand + linker (HY-174432))[1].
Molecular Weight:
852.40
Formula:
C45H51ClFN9O5
Target:
JAK,PROTACs,STAT
Application Notes:
MCE Product type: Reference compound
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