Nsp12-IN-2 (Compound 8), the triphosphate metabolite of 4-thiouridine (HY-W113081), is a SARS-CoV-2 Nsp12 inhibitor. Nsp12-IN-2 inhibits the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, terminates RNA synthesis and also blocks the RNAylation and NMPylation of Nsp9. Nsp12-IN-2 is promising for research of infections caused by SARS-CoV-2, other coronaviruses, and other RNA viruses[1].
Molecular Weight:
566.15
CAS Number:
[667882-55-5]
Formula:
C9H12N2Na3O14P3S
Target:
Drug Metabolite,SARS-CoV,Virus Protease
Application Notes:
MCE Product type: Reference compound1
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