PROTAC ERalpha Degrader-12 is a potent and selective Eralpha PROTAC degrader. PROTAC ERalpha Degrader-12 has antiproliferative effects in multiple breast cancer cell lines with wild-type or mutant ERalpha. PROTAC ERalpha Degrader-12 can halt the cell cycle and induce cell apoptosis. PROTAC ERalpha Degrader-12 exhibits excellent antitumor and ERalpha degradation activity. PROTAC ERalpha Degrader-12 can be used for research on breast cancer. (Pink: ER ligand-11 (HY-174475), Blue: VHL ligand (HY-112078), Black: Linker (HY-W088749), VHL ligand + Linker ( HY-W998310))[1].
Molecular Weight:
930.34
Formula:
C53H83N7O5S
Target:
Apoptosis,Estrogen Receptor/ERR,PROTACs
Application Notes:
MCE Product type: Reference compound
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