Antitrypanosomal agent 24 is a benzothiazole amidoxime with strong and selective antitrypanosomal activity (IC50 = 0.92 µM). Antitrypanosomal agent 24 is a substrate of the P-glycoprotein efflux pump. Antitrypanosomal agent 24 has high membrane permeability and good metabolic stability. Antitrypanosomal agent 24 binds to DNA/RNA by intercalation[1].
Molecular Weight:
402.49
Formula:
C20H23FN4O2S
Target:
P-glycoprotein
Application Notes:
MCE Product type: Reference compound
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