APH02174 is a highly selective and orally active IRAK4 PROTAC degrader with the DC50 of 4.01 nM in THP-1 cells. APH02174 blocks inflammatory signals by inhibiting IL-6 release. APH02174 can be used for research on inflammatory conditions such as psoriasis vulgaris and rheumatoid arthritis. (Pink: IRAK4 Ligand (HY-174470), Blue: CRBN Ligand (HY-45512), Black: Linker, CRBN Ligand+Linker (HY-174796))[1]
Molecular Weight:
870.00
CAS Number:
[3065494-66-5]
Formula:
C49H55N7O8
Target:
Interleukin Related,IRAK,PROTACs
Application Notes:
MCE Product type: Reference compound
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