APH02174 hemiformic is a highly selective and orally active IRAK4 PROTAC degrader with the DC50 of 4.01 nM in THP-1 cells. APH02174 hemiformic blocks inflammatory signals by inhibiting IL-6 release. APH02174 hemiformic can be used for research on inflammatory conditions such as psoriasis vulgaris and rheumatoid arthritis[1].
Molecular Weight:
916.03
Purity:
98.05
Formula:
C49H55N7O81/2CH2O2
Target:
Interleukin Related,IRAK,PROTACs
Application Notes:
MCE Product type: Reference compound
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