dPDL1-4 is a potent and selective eHSPTAC eHSP90 PD-L1 degrader with DC50s of 7.77 µM and 6.52 µM in HeLa and B16F10 cells. dPDL1-4 bridges eHSP90 with the target protein, inducing lysosomal degradation. dPDL1-4 can degrade PD-L1 significantly and inhibits tumor growth. dPDL1-4 can be used for the study of cervical cancer and melanoma. ((Pink: eHSP90 ligand (HY-174476), Blue: PD-L1 ligand (HY-116274), Black: Linker (HY-W021787), HSP ligand + linker: HY-174799))[1].
Molecular Weight:
1133.17
Formula:
C60H74BrN7O10
Target:
HSP,LYTACs,PD-1/PD-L1
Application Notes:
MCE Product type: Reference compound
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