Bumetanide (Ro 10-6338, PF 1593), a highly potent loop diuretic, is a Na+-K+-Cl+ cotransporter (NKCC) blocker. Bumetanide is a selective NKCC1 inhibitor, but also inhibits NKCC2, with IC50s of 0.68 µM and 4.0 µM for hNKCC1A and hNKCC2A, respectively[1][2].
Molecular Weight:
364.42
Purity:
99.95
CAS Number:
[28395-03-1]
Formula:
C17H20N2O5S
Target:
NKCC
Application Notes:
MCE Product type: Reference compound
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