Embelin (Embelic acid), a potent, nonpeptidic XIAP inhibitor (IC50=4.1 µM), inhibits cell growth, induces apoptosis, and activates caspase-9 in prostate cancer cells with high levels of XIAP. Embelin blocks NF-kappaB signaling pathway leading to suppression of NF-kappaB-regulated antiapoptotic and metastatic gene products. Embelin also induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells[1][2][3].
Molecular Weight:
294.39
Purity:
99.01
CAS Number:
[550-24-3]
Formula:
C17H26O4
Target:
Apoptosis,Autophagy,IAP,NF-kappaB
Application Notes:
MCE Product type: Natural Products
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