XL-3156 is a potent, selective, and cross-species cGAS inhibitor. XL-3156 can simultaneously occupy both allosteric and orthosteric sites, and inhibit the interaction and phase separation between cGAS and DNA by stabilizing the closed conformation of the activation loop. XL-3156 can be used in the research of autoimmune diseases, inflammatory conditions and other diseases[1].
Molecular Weight:
517.54
Purity:
99.91
Formula:
C28H23N9O2
Target:
Cyclic GMP-AMP Synthase
Application Notes:
MCE Product type: Reference compound
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