AZ320 is an ATP-competitive necroptosis (EC50 of 4.9 µM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ320 can be used for researches of cancer and inflammation[1].
Molecular Weight:
416.51
Formula:
C20H20N2O4S2
Target:
Necroptosis,RIP kinase
Application Notes:
MCE Product type: Reference compound
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