EGFR-IN-164 (Compound 4) is a selective and covalent allosteric EGFR inhibitor. EGFR-IN-164 significantly inhibits the activity of EGFRL858R/T790M/C797S kinase (IC50: 48.1 nM) and proliferation of of EGFR-mutant cells. EGFR-IN-164 can be used for drug resistance of cancer research[1].
Molecular Weight:
484.57
Formula:
C23H21FN4O3S2
Target:
c-Kit,EGFR
Application Notes:
MCE Product type: Reference compound1
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