HTS05585 (Compound Hit-1) is a selective macrophage migration inhibitory factor (MIF) inhibitor with a Kd value of 0.29 µM measured by microscale thermophoresis (MST) and 0.320.01 µM verified by isothermal titration calorimetry (ITC). HTS05585 inhibits the release of pro-inflammatory factors (TNF-alpha, IL-6, IL-1beta) from LPS-induced macrophages. HTS05585 is promising for research of inflammation-related diseases such as sepsis[1].
Molecular Weight:
289.33
CAS Number:
[696643-14-8]
Formula:
C18H15N3O
Target:
Macrophage migration inhibitory factor (MIF)
Application Notes:
MCE Product type: Reference compound
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