dASK1-VHL is an orally active PROTAC degrader targeting ASK1. dASK1-VHL can effectively bind VHL and promote the selective degradation of ASK1. dASK1-VHL effectively reduces ASK1 protein levels, inhibits the activation of p38 MAPK, and reduces liver lipid content. dASK1-VHL provides new ideas for the study of Metabolic dysfunction-associated steatohepatitis (MASH) (Pink: ASK1 ligand 1 (HY-174860), Blue: E3 ligand (S,R,S)-AHPC (HY-125845), Black: Linker, (S,R,S)-AHPC-CO-C2-PEG-NHCO-C2-COOH (HY-174861)[1].
Molecular Weight:
986.10
Formula:
C48H57F2N11O8S
Target:
ASK1,p38 MAPK,PROTACs
Application Notes:
MCE Product type: Reference compound
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