AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 (Kd = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe2+) and ferric (Fe3+) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 (HY-174871), Blue: E3 ligand Pomalidomide (HY-10984), Black: Linker, Pomalidomide-PEG3-acid (HY-174872))[1].
Molecular Weight:
809.95
Formula:
C41H59N7O10
Target:
Ferroptosis,PROTACs
Application Notes:
MCE Product type: Reference compound
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