PROTAC ERalpha Degrader-11 is a selective and intrinsically fluorescent (Ex: 366 nm, Em: 440 nm) ERalpha PROTAC degrader. PROTAC ERalpha Degrader-11 shows good antiproliferative activity, selective ERalpha degradation and imaging capabilities in MCF-7 breast cancer cell lines. PROTAC ERalpha Degrader-11 induces G2/M phase arrest and induces apoptosis in MCF-7 cells. PROTAC ERalpha Degrader-11 is well-tolerated up to a dose of 500 mg/ kg with no acute toxicity in athymic nude mice. PROTAC ERalpha Degrader-11 can be used for the study of breast cancer.(Pink: ERalpha ligand (HY-167701), Blue: CRBN Ligand (HY-150831), Black: Linker, E3 ligase ligand-linker conjugate (HY-174880))[1].
