ITK-IN-6 is a highly potent and selective ITK inhibitor (Kd = 387 nM). ITK-IN-6 directly binds to the ITK kinase domain. ITK-IN-6 blocks the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus and IgE production. ITK-IN-6 significantly inhibits airway inflammation and is used in asthma research[1].
Molecular Weight:
451.32
CAS Number:
[2616666-32-9]
Formula:
C20H16Cl2N2O4S
Target:
Itk
Application Notes:
MCE Product type: Reference compound
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