LC-MF-4 is a selective FGFR3 PROTAC degrader with a DC50 of 30.89 nM in KMS-11 cells. LC-MF-4 inhibits the metabolic function of FGFR3-TACC3 fusion positive cancers with reduction of ATP synthesis and inhibition of mitochondrial biogenesis genes. LC-MF-4 has potent antitumor activity in the Ba/F3-FGFR3-TACC3 xenograft mice model. LC-MF-4 can be used for FGFR3-altered cancers like bladder cancer and urothelial carcinoma (UC) research[1]. Pink: FGFR3 ligand (HY-175414), Blue: VHL ligase ligand (HY-125905), Black: linker (HY-Y1224)
Molecular Weight:
1132.18
Formula:
C56H69Cl2FN10O8S
Target:
ATP Synthase,FGFR,PROTACs
Application Notes:
MCE Product type: Reference compound
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