NEP162 is a BRD4 PROTAC degrader with DC50s of 1.2 and 1.6 µM in SW480 and U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibits tumor growth and induces apoptosis. NEP162 can be used for the study of osteosarcoma, colorectal cancer and non-small cell lung cancer, etc. (Pink: BRD4 ligand : (HY-78695), Blue: E3 ligase Ligand (HY-D2259), BLACK: Linker, E3 ligase ligand-linker conjugate (HY-174997))[1].
Molecular Weight:
926.57
CAS Number:
[3031840-36-2]
Formula:
C50H56ClN11O3S
Target:
Apoptosis,Epigenetic Reader Domain,PROTACs
Application Notes:
MCE Product type: Reference compound
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