L14-8 is a potent ferroptosis inducer. L14-8 promotes PLK1 degradation via ubiquitination, increasing TP53 phosphorylation to enhance SAT1 transcription, thereby triggering ferroptosis and cancer cell death. L14-8 can be used for the study of advanced prostate cancer[1].
Molecular Weight:
517.52
Formula:
C30H25F2NO5
Target:
Ferroptosis,MDM-2/p53,Polo-like Kinase (PLK)
Application Notes:
MCE Product type: Reference compound
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