RIPK1-IN-32 is a RIPK inhibitor with anti-inflammatory activity. RIPK1-IN-32 inhibits nitric oxide (NO) release with an IC50 of 3.26 µM. RIPK1-IN-32 significantly alleviates acute liver injury associated with sepsis through the RIPK1/NF-kappaB/MAPK pathway, therefore preventing the nuclear translocation of p65 and c-fos, which results in reduced expression of TNF-alpha and IL-6. RIPK1-IN-32 can be used for the study of acute liver injury and sepsis[1].
