MRC-G-001 is a Genipin (HY-17389) derivative with an IC50 of 117 µM against A549 cancer cells. MRC-G-001 inhibits the phosphorylation of EGFR, JAK1, and STAT3, and modulates epithelial-mesenchymal transition (EMT)-related protein expression, thereby attenuating cell migration and invasion. MRC-G-001 induces cell cycle arrest and cell apoptosis. MRC-G-001 can be used for the study of cancers such as non-small-cell lung cancer[1].
Molecular Weight:
357.44
Formula:
C21H27NO4
Target:
Apoptosis,EGFR,JAK,STAT
Application Notes:
MCE Product type: Reference compound1
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