PROTAC IRAK4 degrader-13, CAS [[2432992-21-5]] Preis auf Anfrage
Biozol Catalog Number:
MCE-HY-175022
Supplier Catalog Number:
HY-175022
Alternative Catalog Number:
MCE-HY-175022-1UNIT
Manufacturer:
MedchemExpress
Category:
Biochemikalien
PROTAC IRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader with DC50s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod (HY-B0180) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research[1]. Pink: IRAK4 ligand, Blue: E3 ligase ligand, Black: linker
