FAK-IN-28 is an orally active FAK inhibitor (IC50 = 0.4 nM). FAK-IN-28 exhibits dual antiproliferative and anti-metastatic properties. FAK-IN-28 triggers caspase-3-dependent apoptosis via ROS elevation. FAK-IN-28 inhibits tumor growth without causing weight loss or hepatotoxicity. FAK-IN-28 is useful in the study of FAK-driven malignancies, such as colon cancer, cervical cancer, triple-negative breast cancer, and melanoma[1].
Molecular Weight:
795.83
Formula:
C37H40F3N9O6S
Target:
Apoptosis,Caspase,FAK,Reactive Oxygen Species (ROS)
Application Notes:
MCE Product type: Reference compound
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